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The mechanism of action for activation of TRPA1 by this group of NSAID ligands does not involve covalent modification of cysteines as is known for acrolein AITC CA and iodoacetamide. The active compounds do not possess electrophilic groups and their actions on TRPA1 have a fast onset and demonstrate rapid and complete reversibility upon
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Service en ligneIdentification of a selective nuclear import signal in
The adenosine deaminases acting on RNA (ADARs) comprise a family of RNA editing enzymes that selectively modify single codons within RNA primary transcripts with often profound impact on protein function. Little is known about the mechanisms that regulate nuclear RNA editing activity.
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The mechanism of action for activation of TRPA1 by this group of NSAID ligands does not involve covalent modification of cysteines as is known for acrolein AITC CA and iodoacetamide. The active compounds do not possess electrophilic groups and their actions on TRPA1 have a fast onset and demonstrate rapid and complete reversibility upon
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